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J J Hopwood Selected Research

N-sulfoglucosamine sulfohydrolase (sulfamidase)

12/2019Early disease course is unaltered in mucopolysaccharidosis type IIIA (MPS IIIA) mice lacking α-synuclein.
12/2012Exocytosis is impaired in mucopolysaccharidosis IIIA mouse chromaffin cells.
11/2008Primary culture of neural cells isolated from the cerebellum of newborn and adult mucopolysaccharidosis type IIIA mice.
10/2008Effect of high dose, repeated intra-cerebrospinal fluid injection of sulphamidase on neuropathology in mucopolysaccharidosis type IIIA mice.
11/2004Purification and characterization of recombinant murine sulfamidase.
10/2001Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications.
8/2001Prediction of Sanfilippo phenotype severity from immunoquantification of heparan-N-sulfamidase in cultured fibroblasts from mucopolysaccharidosis type IIIA patients.
1/2001A novel missense mutation in lysosomal sulfamidase is the basis of MPS III A in a spontaneous mouse mutant.
6/2000Gene encoding the mouse sulphamidase: cDNA cloning, structure, and chromosomal mapping.

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J J Hopwood Research Topics

Disease

14Mucopolysaccharidosis III (Sanfilippo Syndrome)
12/2019 - 04/2000
8Mucopolysaccharidoses
12/2012 - 04/2000
7Lysosomal Storage Diseases (Lysosomal Storage Disease)
05/2012 - 01/2001
5Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
03/2013 - 10/2001
5alpha-Mannosidosis
01/2008 - 05/2001
5Mucopolysaccharidosis I (Hurler Syndrome)
09/2004 - 04/2000
3Glycogen Storage Disease Type II (Pompe's Disease)
09/2001 - 09/2000
2Neurodegenerative Diseases (Neurodegenerative Disease)
12/2019 - 02/2010
2Disease Progression
12/2019 - 02/2010
1Brain Diseases (Brain Disorder)
12/2019
1Metachromatic Leukodystrophy (Sulfatide Lipidosis)
02/2010
1Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
01/2009
1Globoid Cell Leukodystrophy (Krabbe Disease)
01/2009
1Ataxia (Dyssynergia)
01/2008
1Inborn Genetic Diseases (Disease, Hereditary)
07/2003
1Protein Deficiency
07/2003
1Muscular Diseases (Myopathy)
09/2001
1Body Weight (Weight, Body)
09/2001
1Cardiomyopathies (Cardiomyopathy)
09/2001
1Dementia (Dementias)
12/2000
1Hypersensitivity (Allergy)
04/2000
1Central Nervous System Diseases (CNS Diseases)
01/2000
1Fucosidosis
01/2000

Drug/Important Bio-Agent (IBA)

17EnzymesIBA
12/2012 - 01/2000
10Heparitin Sulfate (Heparan Sulfate)IBA
06/2012 - 04/2000
9N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA
12/2019 - 06/2000
5Proteins (Proteins, Gene)FDA Link
12/2019 - 09/2000
5OligosaccharidesIBA
06/2012 - 05/2001
5alpha-Mannosidase (LAMAN)IBA
01/2008 - 05/2001
4AcidsIBA
11/2008 - 09/2000
4alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA
06/2007 - 11/2000
4Iduronidase (alpha-L-Iduronidase)IBA
09/2004 - 04/2000
3LipidsIBA
06/2012 - 12/2000
3GlycosaminoglycansIBA
05/2012 - 12/2000
3Mannose (D-Mannose)IBA
10/2007 - 05/2001
3alpha-Glucosidases (Acid Maltase)IBA
09/2001 - 09/2000
2HydrolasesIBA
12/2012 - 12/2000
2IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA
11/2004 - 03/2001
2heparan sulfate sulfataseIBA
01/2001 - 04/2000
1SynucleinsIBA
12/2019
1galsulfaseFDA Link
03/2013
1Carbon Fiber (Grafil)IBA
12/2012
1Neurotransmitter Agents (Neurotransmitter)IBA
12/2012
1PhosphatidylglycerolsIBA
06/2012
1GangliosidesIBA
06/2012
1bis(monoacylglyceryl)phosphateIBA
06/2012
1A 7 (A-7)IBA
06/2012
1Sucrose (Saccharose)IBA
06/2012
1ArylsulfatasesIBA
05/2012
1Cerebroside-Sulfatase (Arylsulfatase A)IBA
02/2010
1Sulfoglycosphingolipids (Sulfatides)IBA
02/2010
1Lysergic Acid Diethylamide (LSD)IBA
01/2009
1Recombinant ProteinsIBA
01/2009
1DisaccharidesIBA
11/2008
1Glucosamine (Dona)IBA
11/2008
1Sulfates (Sulfates, Inorganic)IBA
11/2008
1AcetylgalactosamineIBA
03/2005
1lysosomal proteinsIBA
07/2003
1N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA
10/2001
1Nonsense Codon (Nonsense Mutation)IBA
10/2001
1Biological ProductsIBA
10/2001
1GlycogenIBA
08/2001
1Complementary DNA (cDNA)IBA
05/2001
1Gentamicins (Gentamicin)FDA LinkGeneric
02/2001
1SulfatasesIBA
01/2001
1Amino AcidsFDA Link
01/2001
1MetalsIBA
01/2001
1AcetylglucosamineIBA
12/2000
1Uronic AcidsIBA
12/2000
1alpha-L-Fucosidase (Fucosidase)IBA
01/2000
1Sepharose (Agarose)IBA
01/2000

Therapy/Procedure

10Enzyme Replacement Therapy
03/2013 - 01/2000
5Therapeutics
03/2013 - 09/2001
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
11/2001 - 01/2000
1Stem Cell Transplantation
06/2012